Without obesity.. “a gene” allows people to eat whatever they want

A recent scientific study has revealed that by disabling a gene, they can eat whatever they want without becoming obese.

After conducting experiments on mice, experts from the University of California San Diego discovered that a genetic cause causes fat cells to lose their ability to burn energy, according to a study published in the journal “Nature Metabolism.”

Researchers found that when rodents eat a high-fat diet, their cells break down and become less efficient at burning fat, which may explain why obesity causes a slower metabolism in humans.

They discovered that this process is controlled by a single gene that, when removed through gene editing, prevented the rodents from gaining excess weight, even when fed the same high-fat diet.

“Mitochondria,” a double-membrane cellular organelle that produces the energy needed to run the body and help burn fat, and aging is linked to a decline in its function, they found, is the most important organelle. Achieving the results of the study.

The researchers measured the effect of a high-fat diet on the mice's “mitochondria.” After the meal, the mice were divided into smaller, less efficient cells, which led to less fat burning. This is achieved by a single gene (RaIA). ).

The researchers' findings show that when this gene is overactive, it inhibits the normal function of mitochondria, which leads to fat cells not burning energy.

“Excess calories from overeating can trigger a cascade of metabolic processes that lead to weight gain, decrease energy expenditure, and worsen obesity,” says Alan Salthill, professor of medicine at the University of California, San Diego and lead author of the study. “The gene we found is a key part of this transition from healthy weight to obesity.”

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When people consume more calories than they burn, fat cells begin to fail in their ability to burn energy, which is one of the reasons why it is difficult for obese people to lose weight, but how fat cells fail is one of the biggest mysteries. obesity.

“The direct comparison between the basic biology we discovered and the actual clinical results underscores the importance of the findings for humans, and new therapies targeting the RaIA pathway could help treat or prevent obesity,” explained Salthill. The metabolism of this disease is complex, but the future possibilities are exciting.”

Future treatments include gene therapies, or CRISPR, a technology scientists use to modify DNA in living organisms to eliminate RaIA and its effects on the body.

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