Drugs given in late stages of breast cancer also protect healthy women


Saturday, March 30, 2024 04:43 PM

The newspaper revealed“IndependentA drug discovery could help people with defective genes avoid surgery Breast CancerIt comes after researchers found symptoms in the immune cells of women with a mutation in the BracA gene BRCA

Drugs commonly given in late-stage breast cancer can prevent the disease from developing in healthy people with the defective genes, a study suggests. Mutation.BRCA This exposes them to the risk of breast, ovarian and other cancers – apart from surgery.

It comes after academics at the University of Cambridge discovered immune cells in the breast tissue of healthy women carrying the genes. BRCA1 Or BRCA2 A defective one showed signs of a defect known as “burn-in”.“.
This mechanism – usually seen in late-stage tumors – indicates that the immune cells cannot eliminate damaged cells, which eventually leads to cancer. There are already drugs to overcome this obstacle in the activity of immune cells, but so far only one has been approved, which is used only for the treatment of late stages of the disease..

Lead researcher Professor Walid Khalid, from the Department of Pharmacology at the University of Cambridge and the Wellcome MRC Cambridge Stem Cell Institute, said: “There are immunological drugs that block this activity late in the disease.”.
He added, “We are very excited about this discovery because it opens up the possibility of a preventive treatment other than surgery for carriers of breast cancer gene mutations.”” .” BRCA
Immunotherapy helps the immune system detect and fight cancer. It can be given alone or in combination with other treatments..

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Professor Khalid emphasized: “Nobody had really thought about using them in a preventative way before.” However, these drugs have serious side effects and we are testing them in pre-clinical models to find safe doses before going ahead with them. For human studies..”

According to the NHS, she is one in 100 women with the mutation BRCA1 About one in every 100 women with the mutation will develop breast cancer between the ages of 65 and 85, while those between the ages of 40 and 63 will develop ovarian cancer. BRCA2Between 40 and 85 women will develop breast cancer at some point in their lives. In some cases, patients with defective genes may be offered surgery to reduce the risk of removing tissues such as breasts or ovaries that may become cancerous. Funded by the Foundation, the Cancer UK Cambridge Research Group provided the inhibitory biology to test the method in mice, and closely monitored side effects and doses..

The paper says the best weapon we have against breast cancer is the ability to prevent it in the first place, and then to conduct clinical trials in women with the genetic mutation. “PRCA”.

Professor Khalid added: “The best way to prevent… Breast Cancer The key is to first understand how it develops, so we can recognize and intervene in these early changes. Late-stage breast cancer can be unpredictable and difficult to manage, and as we develop better and better drugs, tumors will appear. You have to find a way to overcome them..
Dr Simon Vincent, director of research, support and impact at Breast Cancer Now, said: “The best weapon we have against breast cancer is the ability to prevent it in the first place..
The research, which used tissue samples from the Breast Cancer Foundation's Tissue Bank Now, suggests that using drugs currently approved to treat late-stage breast cancer could prevent some women with the variant genes from developing the disease..

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Although more research is needed and clinical trials in humans have yet to be conducted, the results could be an important step forward in the care and treatment of individuals with genes that make them more susceptible to breast cancer, the paper added. Done – it was published in a journal Natural Genetics – A Cambridge research team was developing a comprehensive catalog of human breast cells.

More than 800,000 cells from 55 women are included in the so-called Human Breast Cell Atlas, which is available for other researchers to use and add, and which also contains information on other risk factors for breast cancer, such as body mass. index. (BMI)Contraceptive use, alcohol consumption and menstruation.

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